The 10 Best Girl Power Isekai Anime With A Strong Female MC

Are you tired of seeing the usual stereotyped male MC in isekai anime defeat the villain with his sharp sword and then throw himself into the arms of the princess?

That’s exactly why we have written for you the list of the best isekai anime with a strong female lead, with choices that explore different themes to please all tastes.

10. So I’m a Spider, So What? – Kumoko

So I’m a Spider, So What? is a quirky isekai anime that was released in 2021.

The story revolves around a group of students who were reincarnated in an alternate world after being caught in the crossfire caused by the battle between the Hero and the Demon King in another dimension.

Everyone seems to have kept their normal appearance, but to everyone’s surprise, the protagonist is reincarnated as a spider and must quickly adapt to her new life.

While the premise may seem interesting, the anime kinda falls short in terms of innovation. Not to mention that the beginning of the show is kinda slow-paced, so you will need to be patient.

However, if you are willing to wait, the story becomes slightly more interesting as it progresses, and the protagonist becomes a cool and quite strong female lead.

This is also a good isekai anime with experience levels if you like the subgenre.

9. Tricks of the Gods – Yui Kusanagi

Tricks of the Gods is a 2014 anime released in 12 episodes, belonging to the reverse-harem, fantasy and supernatural genres.

The sons of Zeus are gorgeous and strong, but they have one flaw: they are all spoiled males who don’t know love.

This is why Yui, an ordinary Japanese girl, will be chosen and summoned by Zeus himself to teach this complicated feeling to his sons!

Tricks of the Gods is a simple and unpretentious anime, focusing on comic scenes as the gods will try to win Yui over.

It must be admitted, however, that to stand up to the sons of Zeus himself one must be a respectable female protagonist!

8. The Saint’s Magic Power is Omnipotent – Sei Takanashi

The Saint’s Magic Power is Omnipotent is a recent isekai, released during spring 2021 in 12 episodes by far.

Sei is a girl who, after a long day’s work, ends up being summoned to the mysterious Kingdom of Slantania as a Saint charged with protecting it from the threat of monsters that are wreaking havoc.

But upon her arrival in this world, it turns out that the great Magus has accidentally summoned two Saints, Sei and another brown-haired girl.

Needing only one Saint, however, the other girl will be chosen, and Sei will end up having to create a new life from scratch in this new world.

The Saint’s Magic Power is Omnipotent is a good isekai, with no particular merits or flaws.

If you are looking for a good story with a good female lead, without any particular twists or innovations, we recommend it.

7. BOFURI: I Don’t Want to Get Hurt, So I’ll Max Out My Defense. – Kaede Honjou

BOFURI is a good isekai with a different premise than usual, released in 2020 in 12 episodes with many comic, action and MMORPG elements.

Kaede Honjou, who’s new to online MMORPGs, joins the latest released MMORPG game, invited by her friends.

As a beginner, Kaede chooses a large shield as her weapon and levels it up, to avoid being hurt.

But to everyone’s surprise, the tactic proves to be incredibly effective, and she quickly becomes incredibly OP and a legend in the server!

If you are tired of the usual swordsman or wizard protagonists and want to explore a new perspective, give BOFURI a chance.

Its atmospheres are comical and almost parodic of the isekai genre, but you will also find excellent action scenes.

6. My Next Life as a Villainess: All Routes Lead to Doom! – Katarina Claes

My Next Life as a Villainess: All Routes Lead to Doom! is another isekai with a unique premise that we are sure will keep you entertained in its 12 episodes.

The story follows Catarina, a young girl who, after being hit by a rock on the head, finds herself reincarnated as the villainess of the videogame she was playing before dying.

The problem? Catarina knows that her character dies in every possible route!

Despite being destined for a bad ending in all routes, Catarina sets out to create her own happy ending, going against her fate.

This is a good isekai, with an innovative plot narrated in a light and entertaining way, with many comic scenes and plot twists led by a funny and great female MC.

5. The Devil is a Part Timer! – Emi Yusa

The Devil is a Part-Timer! is a 13-episode anime adapted from the Light Novel of the same name.

The demon king is finally one step away from conquering his world when he’s suddenly mysteriously transported to Tokyo.

And instead of getting discouraged, he decides to conquer this new world too. But first, he needs to conform to society and make some money. So, he starts working part-time at a fast-food restaurant.

But this does not mean that he will be outside of trouble and danger, as Emi Yusa, the hero of his old world, has pursued Satan to planet Earth to defeat him for good.

The Devil is a Part Timer! is a unique and incredibly underrated isekai. Its story is incredibly entertaining and almost a parody of the genre, with top-level comic and action moments.

The relationship between Satan and Emi also is excellent and with a lot of evolution, not to mention that Emi is an excellent female lead in the genre.

4. Spirited Away – Chihiro Ogino

Spirited Away is one of Studio Ghibli’s best movies, that even received Oscar nominations and awards, and one of the best fantasy anime ever made.

And yes we know, it’s strange, but Spirited Away is an isekai in its own right if you think about it.

Chihiro is a little 10 years girl, who together with her parents is moving to a new town. On the way, they will stop in front of a strange building in the middle of the woods, which the parents decide to explore in curiosity, leaving the little girl alone in the car.

Chihiro will decide to join them, scared of being alone, and from here a journey you can’t even imagine will begin where she’ll meet every type of creature.

Spirited Away is a must-watch animation gem, period. Its animations are excellent, as are the characters and their design.

Chihiro is also one of the best female protagonists in the genre, who faces tough situations as a child without too many problems.

3. Saga of Tanya the Evil – Tanya von Degurechaff

Saga of Tanya the Evil is an excellent isekai with politics released in 2017 that we absolutely recommend watching.

It follows the story of Tanya, a young blonde girl who appears innocent but is actually a merciless and strong warrior on the battlefield, leading the Imperial Army.

Tanya was previously a Japanese bureaucrat, who was reincarnated as a child in a world destroyed by war due to his cynicism and blasphemy.

But instead of being desperate, he chose to rule this new world too with his undisputed intellect.

If you are a fan of isekai set in a warlike, realistic context that deviates from the usual fantasy settings, then Saga of Tanya the Evil is probably your best choice.

Tanya is also an excellent, ruthless, strong, and incredibly intelligent female protagonist that will stick with you.

2. Sonny Boy – Mizuho and Nozomi

Sonny Boy is an underrated isekai released in 2021 in 12 episodes that will keep you glued on the screen from the beginning to the end.

At the beginning of what was supposed to be an ordinary summer school break, a school is mysteriously transported to another world.

And that’s how 36 students will find themself in the dark, unable to contact the outside world as they begin to develop special powers.

But among these students, the personalities of Asakaze and Nagara, 2 excellent male MCs, and Mizuho and Nozomi, two strong female MCs, will stand out.

That’s the beginning of a deadly struggle for survival, filled with betrayal, death, and plot twists.

Sonny Boy is a little gem, with a unique graphic style and a simple but impressive plot full of twists.

1. Ascendance of a Bookworm: Stop at Nothing to be a Librarian – Myne

Ascendance of a Bookworm: Stop at Nothing to be a Librarian is an interesting 2019 isekai without romance with 36 episodes.

The protagonist, Urano Motosu, is a young college student with a passion for books.

She reads anything she can get her hands on and has a dream of becoming a librarian. But tragically, she dies in an accident just as she’s close to achieving her dream.

Her last wish is to be able to read more books in her next life, and that’s how she reincarnates as Myne, a five-year-old girl living in a medieval era where books are made by being copied by hand. Her new life begins here!

Ascendance of a Bookworm: Stop at Nothing to be a Librarian is a unique isekai, which doesn’t focus on the usual stories of kingdoms to save and monsters to defeat, but on a theme of its own.

If you are looking for a unique story with an interesting female protagonist, you must watch it.