Changing atmosphere now and then fits, to get out of one’s comfort zone, or even simply to try something new, to get out of monotony.
And why shouldn’t this also apply to anime? We’ve already seen the best anime set in America, so why not also go to the ones close by, in South America, to expand the picture?
We will see the most diverse settings in the most diverse states, from Mexico to Venezuela to even the ancient Incas. Enjoy your reading.
But before we start: we remember that as always this listicle is purely based on our opinions and knowledge.
Table of Contents
7. Jinki Extend

Jinki Extend is one of the many mecha anime that has gone unnoticed among the huge competition in the genre. It was released in the early 2000s and featured only 13 episodes.
The anime is divided into 2 distinct parts, with even very detached settings between them. The first in Venezuela in 1988, and the second in the United States.
Instead, the story is based on two girls who pilot robot humanoids called Jinki, with the fate of having to challenge each other.
Fun fact: this is the first anime in history to feature Venezuela as a setting.
6. From the Apennines to the Andes

Released in 1976, From the Appenines to the Andes is a 52-episode drama adventure inspired by Cuore, an educational novel by Italian author Edmondo De Amicis.
Marco is a Genoese child who lives with his father anxiously waiting for letters from his mother, in Argentina on business.
But suddenly his mother stops being heard, plunging the boy into a state of worry.
This will cause him to board a ship bound for South America in search of his mother.
5. Heavy Object

Heavy Object is a war-themed anime focused on futuristic mecha fighting, released in 2015. Even with the addition of ecchi elements, this series didn’t achieve the success it had hoped for.
In a future world where technological progress has made great strides, the introduction of powerful machines called Objects has changed warfare forever.
The anime is set mainly in America, but one of the main territories of the anime blatantly references South America.
We are talking about the Iguazu District, a fictional territory that includes the really existing Brazil and Argentina, and is also one of the battlegrounds of the anime.
4. Golgo 13: Queen Bee

One of the OAVs of Golgo 13, one of the most famous and popular works of espionage and secret agents ever.
Golgo is hired by presidential candidate Robert Hardy’s adviser to eliminate Queen Bee, the beautiful and deadly leader of a South American army.
Golgo finds this job too easy and begins to sense that there is definitely something more going on.
The setting often oscillates between the U.S. and South America, but the South American setting is all there.
3. The Mysterious Cities Of Gold

A 39-episode sci-fi adventure produced by Pierrot studio and released back in 1982, with a great vintage flavor.
The story takes place in South America when the Spanish conquistadores roamed the New World in search of Native American treasures.
The main characters are Estéban, a Spanish boy, and his friend Lia, a girl belonging to an Inca tribe. Since it’s an adventure, their goal will be to find the legendary city of El Dorado.
The Mysterious Cities of Gold is good in terms of pacing and plot, even though it may seem a little bit outdated in terms of character design.
If you are nostalgic and you want to watch a cult of the ’80s, you are in the right place.
2. El Cazador De La Bruja

The story begins in Mexico on the day that Nadie, a young and extroverted bounty hunter, meets Ellis, a girl with a mysterious past. Ellis’ ability allows her to manipulate the molecules of the elements.
The plot of the story subsequently unfolds through the mysteries involving Ellis’ past, but especially the journey the two girls take together and their relationship.
Their journey will take us into the Mexican deserts, giving us a setting and wild west vibes of fine workmanship.
The great character design and the presence of woman gunslingers are good reasons to watch this show. Nadie and Ellis are an excellent duo and they complement each other, making this one of the best Wild West anime.
1. Michiko and Hatchin

Series from the late 2000s are marked by a recognizable imprint of those years, both as animation but also in terms of themes and costumes.
The story, set in a fictional Latin American country named Diamandra, revolves around two women.
Michiko, who has just escaped from a maximum-security penitentiary prison, and Hatchin, an orphan girl adopted by the family of a local clergy member. The tranquility of the two isn’t destined to last though.
The right anime if you want to plunge into the 2000s and experience some Latin atmosphere rendered superbly by Manglobe studio, the same as no less than Samurai Champloo, in one of the best anime set in America.